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Research/Senior Research/Principal Scientists

Employer: FUJIFILM Diosynth Biotechnologies UK

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Jobs E-bulletin issue no: 857/300817 Date job posted: 29 August 2017

FUJIFILM Diosynth Biotechnologies is a biopharmaceutical company within FUJIFILM corporation with development and manufacturing sites in Billingham & Wilton, UK, Research Triangle Park, North Carolina and College Station, Texas, USA employing over 1000 staff. Globally we have over 35 years of clinical and commercial experience in biopharmaceutical development and cGMP manufacturing. We are one of the world's leading GMP drug Contract and Development Manufacturing Organisations (CDMO) through the continuous innovation of technologies, service delivery and quality – contributing to the enhancement of the quality of life of people worldwide.

We are recruiting a number of scientists in Analytical, Upstream and Downstream Platform Operations in our Research & Development department within FUJIFILM Diosynth Biotechnologies, Wilton, UK in a brand new, state of the art facility. Highly motivated individuals are sought to join a group of scientists working to establish recombinant monoclonal antibody platform processes suitable for the manufacture of biotherapeutics. The available positions are for Research Scientists / Senior Research Scientists / Principal Scientists based on qualifications and experience in one of the following platform operations groups: analytical methods, mammalian cell culture or protein purification.

The successful candidates will be laboratory-based and working as part of teams:
• Analytical Platform Operations: Involved in the establishment and qualification of analytical methods using chromatography, spectroscopic (includes plate assays and LCMS) and biophysical characterisation techniques. Providing analytical support to both upstream and downstream platform operations groups.
• Upstream Mammalian Cell Culture Platform Operations: Involved in the establishment and evaluation of upstream processes to produce robust and reproducible processes resulting in consistent critical product quality and yields using Ambr and XDR technology.
• Downstream Platform Operations: Involved in the establishment of platform downstream processes to enrich and purify monoclonal antibodies from laboratory to large scale.

Education and Experience
• Research Scientist: A life science degree (BSc / MSc) with relevant biotech/pharmaceutical industry experience within the areas advertised
• Principal Scientist: PhD with/without post-doctoral study-level or equivalent relevant biotech/pharmaceutical industry experience within the areas advertised

Technical Skills Requirements
• Sound knowledge of analytical methodologies to support the characterisation of recombinant proteins
• Practical experience of the analytical techniques of chromatography, electrophoresis and spectroscopy(ELISA, plate assays). LCMS and biophysical techniques would be beneficial
• Understanding of the requirement to qualify/validate methodologies to support GMP manufacture

Upstream Mammalian Cell Culture
• Knowledge of mammalian cell line expression platforms and / or cell culture process development strategies
• Practical experience in aseptic technique and mammalian cell culture (ideally CHO based) methods
• Experience of transfection / cloning techniques and / or operation and control of stirred tank, laboratory scale (1-10L) mammalian cell culture bioreactors a plus

• Knowledge of protein purification strategies for the isolation and purification of recombinant proteins
• Practical experience in utilising a range of downstream processing techniques including chromatography and filtration.

Other Competencies
All positions
• Be flexible, self-motivated and have the ability to work as part of a team
• Ensure a high standard of science and quality of work are maintained
• Contribute to the efficient running and continuous improvement initiatives of your functional area within the multi-disciplinary, team orientated R&D department
• Able to communicate progress of projects by both verbal presentations and written reports to both internal and external customers

Senior positions
• Capable of designing and delivering experiments and writing protocols and reports
• Contribute to the implementation of new and innovative ways of working
• Interface with all of your respective development streams within the UK and the USA

Location: Wilton, Redcar, TS10 4RF.
Type: Permanent
Basis: Full Time
Salary Details: £21,902 to £42,098  Competitive salary plus company bonus scheme. Up to 35 days of holiday, plus bank holidays. Salary Sacrifice scheme offering childcare vouchers, bikes, dental etc. Generous pension scheme
Method of application: Online
This includes additional information on all of the positions and our application form, please note we do not accept CVs.
If we have not contacted you within four weeks of the closing date, please assume that you have not been shortlisted on this occasion.
Contact name for applications: HR & OD Team

Web Site:
Informal enquiries to discuss the post in more detail: Emma McEwan, Saturn Systems Manager, Biotechnology on or Simon Uphill, Head of Platform Operations Group, Biotechnology on
Closing Date: 18 September 2017

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