Projects

Exercise improving surgical outcomes

My clinical research focuses on exercise science and health research methodology. Since 2006 I have collaborated successfully with researchers at James Cook University Hospital, Middlesbrough, and more recently EHS Hospital, Morges, Switzerland. Our work spans two main themes; exercise testing and training studies in a variety of patient groups [1, 2], and industry-sponsored clinical trials in patients with chronic intractable pain. Our ultimate aim is to translate our research findings into real patient benefit.

Exercise improving surgical outcomes

In the exercise prehabilitation/ rehabilitation research area, our latest project is a feasibility study of high-intensity interval exercise training before abdominal aortic aneurysm surgery (http://www.controlled-trials.com/ISRCTN09433624). Related studies include a trial of exercise rehabilitation in survivors of critical illness, in which we observed clinically significant benefits in physical fitness. Both of these randomised trials were funded by the National Institute for Health Research.

The exercise testing and training research programme involves researchers from across the University, including Professor Denis Martin (Health and Social Care Institute), Dr Matthew Weston (Social Futures Institute), and Professor Dr Gerard Danjoux (Department of Academic Anaesthesia at James Cook), a visiting professor here at Teesside.

My recent research in the field of chronic pain includes randomised trials on novel drug delivery systems and approaches [3, 4] and spinal cord stimulation. Early in 2013, we reported the findings of the first successfully patient- and observer-blinded trial of spinal cord stimulation - a considerable design and methodological challenge [5]. This research stream is funded by Medtronic, a world-leading company in medical device technology and therapy.

  1. Kothmann E, Batterham AM, Owen SJ, Turley AJ, Cheesman M, Parry A, Danjoux G: Effect of short-term exercise training on aerobic fitness in patients with abdominal aortic aneurysms: A pilot study. Br J Anaesth 2009, 103(4):505-510.
  2. Sinclair RCF, Batterham AM, Davies S, Cawthorn L, Danjoux GR: Validity of the 6 min walk test in prediction of the anaerobic threshold before major non-cardiac surgery. Br J Anaesth 2012, 108(1):30-35.
  3. Perruchoud C, Eldabe S, Durrer A, Bovy M, Brookes M, Madzinga G, Garner F, Batterham AM, Menoud C, Jacobs M et al: Effects of Flow Rate Modifications on Reported Analgesia and Quality of Life in Chronic Pain Patients Treated with Continuous Intrathecal Drug Therapy. Pain Med 2011, 12(4):571-576.
  4. Mohammed SI, Eldabe S, Simpson KH, Brookes M, Madzinga G, Gulve A, Baranidharan G, Radford H, Crowther T, Buchser E, Perruchoud C, Batterham AM: Bolus Intrathecal Injection of Ziconotide (PrialtĀ®) to Evaluate the Option of Continuous Administration via an Implanted Intrathecal Drug Delivery (ITDD) System: A Pilot Study. Neuromodulation 2012, Dec 3. doi: 10.1111/ner.12003. [Epub ahead of print].
  5. Perruchoud C, Eldabe S, Batterham AM, Madzinga G, Brookes M, Durrer A, Rosato M, Bovet N, West S, Bovy M, Rutschmann B, Gulve A, Garner F, Buchser E: Analgesic Efficacy of High-Frequency Spinal Cord Stimulation: A Randomized Double-Blind Placebo-Controlled Study. Neuromodulation 2013, Feb 20. doi: 10.1111/ner.12027. [Epub ahead of print].