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Health and Social Care Institute
Dr. Helen Handoll is a Senior Research Fellow at Teesside University. She trained as a scientist, with a DPhil from Oxford University on Crystallographic Studies of Proteins and then gained experience in clinical trials and overviews while working as a Research Programmer at the Clinical Trials Service Unit, Oxford. Subsequently, while working as the Managing Editor of the Cochrane Bone, Joint and Muscle Trauma Group, she gained experience in systematic reviews of interventions for preventing and treating musculoskeletal injuries, primarily osteoporotic fractures.
Her research interests focus on getting the evidence to inform the management of people with hip, shoulder and wrist fractures, either via primary research (the PROFHER trial) or conducting Cochrane systematic reviews.
Helen is the Co-ordinating Editor of the Cochrane Bone, Joint and Muscle Trauma Group. She is a grant holder and member of the trial management team of the PROFHER trial, which is a pragmatic multi-centre randomised controlled trial that aims to evaluate the effectiveness and cost effectiveness of surgical versus non-surgical treatment for upper arm fractures in adults. This is funded by the National Institute for Health Research (NIHR) Health Technology Assessment Programme and it is a joint collaboration between Teesside University (trial sponsor), James Cook University Hospital and University of York. The main reports of the PROFHER trial were published in March 2015; a long term follow-up is ongoing.
· Treatment and rehabilitation of fractures of the wrist, shoulder and hip in adults
· Role of surgery for shoulder and wrist fractures in adults
· Systematic review and randomised clinical trial methodology
The impact of Helen's work is illustrated as follows:
1. The citation of the full HTA report of the PROFHER trial as the key source of evidence for the 'strong recommendation' for conservative (non-surgical) treatment of proximal humeral fractures in the NICE guidelines: Fractures (non-complex): assessment and management. (February 2016).
2. By the use of her Cochrane Reviews in NICE and SIGN guidelines:
a. The management of hip fracture in adults. (June 2011)
b. Management of hip fracture in older people (June 2009)
External research funding
· 'Proximal Fracture of Humerus Evaluation by Randomisation’ (PROFHER) (2008)
· Cochrane Bone Joint and Muscle Trauma Group (2009-2014 & 2015-2020 as PI)
External research collaboration
· Work on the PROFHER trial, which is a joint collaboration between Teesside University (trial sponsor), James Cook University Hospital and University of York.
· Co-ordinating Editor of the Cochrane Bone, Joint and Muscle Trauma Group, based in University of Manchester.
· Work on various Cochrane reviews with collaborators in the UK and other countries. These are too numerous to list – but are clear from published work.
'Classification of shoulder impingement by ultrasound-guided local anaesthesia’ (completed 2007).
‘Predicting the outcome of conservative treatment with physiotherapy for shoulder pain in the presence of atraumatic, partial-thickness tears of the rotator cuff.’
Four selected publications since 2014
· Handoll H, Brealey S, Rangan A, Keding A, Corbacho B, Jefferson L, et al. The ProFHER (PROximal Fracture of the Humerus: Evaluation by Randomisation) trial – a pragmatic multicentre randomised controlled trial evaluating the clinical effectiveness and cost-effectiveness of surgical compared with non-surgical treatment for proximal fracture of the humerus in adults. Health Technology Assessment 2015;19(24).
· Rangan A, Handoll H, Brealey S, Jefferson L, Keding A, Corbacho Martin B, Goodchild L, Chuang LH, Hewitt C, Torgerson D, for the PROFHER Trial Collaborators. Surgical vs nonsurgical treatment of adults with displaced fractures of the proximal humerus: The PROFHER randomized clinical trial. JAMA 2015;313(10):1037-1047.
· Handoll HHG, Elliott J. Rehabilitation for distal radial fractures in adults. Cochrane Database of Systematic Reviews 2015, Issue 9. Art. No.: CD003324.
· Handoll HHG, Brorson S. Interventions for treating proximal humeral fractures in adults. Cochrane Database of Systematic Reviews 2015, Issue 11. Art. No.: CD000434.
View Helen Handoll's Publications on TeesRep
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