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Ahmad Khundakar

T:
01642 342438
Job title:
Senior Lecturer in Biomedical Science
E:
a.khundakar@tees.ac.uk
School/department:
School of Science, Engineering & Design
 
Follow Ahmad Khundakar on Twitter More about Ahmad Khundakar  
Research:
Science, Engineering and Design research
 
 
ORCID:
0000-0002-4835-5359

About Ahmad Khundakar

Ahmad Khundakar

Ahmad Khundakar
Senior Lecturer in Biomedical Science, School of Science, Engineering & Design
T: 01642 342438
E: a.khundakar@tees.ac.uk
Research: Science, Engineering and Design research

Ahmad is a Senior Lecturer at Teesside University and Associate Lecturer at the Institute of Neuroscience, Newcastle University. He has a broad base of expertise in biomedical science and neuroscience and has published and presented extensively in neuropharmacology and neuropathology. 

He currently leads the Clinical Pharmacology and Molecular and Cellular Pathology module on Biomedical Science degree and is a Fellow of the Institute of Biomedical Sciences. 



Research interests

Ahmad's research mainly involves investigating the molecular and pathological mechanisms behind depression, as well as neurodegerative illnesses, such as Alzheimer’s disease and dementia with Lewy bodies, using post-mortem brain tissue.

Ahmad previously supervised a National Institute for Health Research-funded laboratory-based PhD project examining the role of the thalamus in visual hallucinations in dementia with Lewy bodies and is currently co-supervisor of a laboratory-based Alzheimer's Society-funded Doctoral Training Centre PhD project, examining the role of the anterior cingulate cortex in depression in dementia with Lewy bodies.

He also has expertise in neuropharmacology, with his PhD focusing on the mechanisms of action of antidepressant drugs in the hippocampus.

Research projects & external funding

Co-investigator. 2015–2019. ‘Understanding the basis and interaction of non-cognitive and cognitive symptoms in dementia with Lewy bodies’. Alzheimer’s Society Doctoral Training Centre Grant. £350,000. Applicants: Thomas AJ, Morris CM, Attems JA, Khundakar AA, Taylor JP, Rochester L, LeBeau F, Blamire A, Galna B, Gallacher P

External research collaborations

Ahmad is part of the Neurodegenerative Pathology Research Group at Newcastle University, led by Professor Johannes Attems.

https://research.ncl.ac.uk/ndprg/

Learning and teaching interests

Ahmad currently leads two modules in Molecular and Cellular Pathology and Clinical Pharmacology on the Biomedical Science undergraduate degree, as well as lecturing on numerous modules within the School of Science, Engineering and Design, Teesside University.

Ahmad also teaches on the NHS Northern Deanery Regional MRCPsych Course for psychiatry trainees.

Publications


Unger MS, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar AA, Roßner S, Heneka MT, Couillard-Despres S, Rockenstein D, Masliah E, Attems J, Aigner L. Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?. Alzheimer's & Dementia 2018, Apr 6. pii: S1552-5260(18)30071-2. doi: 10.1016/j.jalz.2018.02.017
Erskine D, Ding J, Thomas AJ, Kaganovich A, Khundakar AA, Hanson PS, Taylor JP, McKeith IG, Attems J, Cookson MR, Morris CM. Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies. Movement Disorders. 2018 Mar 23. doi: 10.1002/mds.27333.
Erskine D, Thomas AJ, Taylor JP, Savage MA, Attems J, McKeith IG, Morris CM, Khundakar AA. Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies. The American Journal of Geriatric Psychiatry 2017, (In Press, Corrected Proof). doi: 10.1016/j.jagp.2017.01.005
Walker L, McAleese KE, Johnson M, Khundakar AA, Erskine D, Thomas AJ, McKeith IG, Attems J. Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts. Journal of Neural Transmission 2017, (ePub ahead of Print). doi: 10.1007/s00702-017-1702-2.
Erskine D, Thomas AJ, Taylor J-P, McKeith IG, Attems J, Morris CM and Khundakar AA.
Specific patterns of neuronal loss in the pulvinar nucleus in dementia with Lewy bodies. Movement Disorders. 2016. In Press. Mar;32(3):414-422. doi: 10.1002/mds.26887.
Khundakar A, Hanson PS, Lax, N Karyka E, Gribben A, Calver H, Scholey M, Ramsey L, Attems J, Wilson KE, Blain PG, Mosimann UP, Xiang CC, Brownstein MJ, Elstner M, Turnbull DM, O’Brien JT, McKeith IG, Morris CM. Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations. Acta Neuropathologica Communications. 2016. In Press. DOI: 10.1186/s40478-016-0334-3
Erskine D, Khundakar AA. Stereological approaches to dementia research using human brain tissue.
Journal of Chemical Neuroanatomy. 2016 Jan 14. pii: S0891-0618(16)00006-5. doi: 10.1016/j.jchemneu.2016.01.004. [Epub ahead of print].
Erskine D, Patterson L, Firbank MJ, Onofrj M, Taylor JP, O’Brien JT, McKeith IG, Attems JA, Thomas AJ, Morris CM and Khundakar AA. Morphometric and neuropathological analysis of the lateral geniculate nucleus in dementia with Lewy bodies. Neuropathology and Applied Neurobiology. 2015 May 12. doi: 10.1111/nan.12249. [Epub ahead of print].
Khundakar AA, Thomas AJ. Neuropathology of Depression in Alzheimer's Disease: Current Knowledge and the Potential for New Treatments. Journal of Alzheimer's Disease. 2015;44(1):27-41. doi: 10.3233/JAD-148003.
Foster V, Oakley AE, Slade JY, Hall R, Polvikoski TM, Burke M, Thomas AJ, Khundakar A, Allan LM, Kalaria RN. Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias. Brain. 2014, 137(9), 2509-2521.
Khundakar AA, Thomas AJ. Cellular Morphometry in Late-Life Depression: A Review of Postmortem Studies. American Journal of Geriatric Psychiatry. 2014, Feb;22(2):122-32. doi: 10.1016/j.jagp.2013.06.003.
Gemmell E, Tam E, Allan L, Hall R, Khundakar A, Oakley AE, Thomas A, Deramecourt V, Kalaria RN. Neuron Volumes in Hippocampal Subfields in Delayed Poststroke and Aging-Related Dementias. Journal of Neuropathology and Experimental Neurology. 2014, 73(4) 305-311.
Burke MC, Nelson L, Slade JY, Oakley AE, Khundakar AA, Kalaria RN. Morphometry of the hippocampal microvasculature in post-stroke and age-related dementias. Neuropathology and Applied Neurobiology. 2014 Apr;40(3):284-95. doi: 10.1111/nan.12085.
Zetterström TSC, Coppell AA, Khundakar AA. The role of 5-hydroxytryptamine receptor subtypes in the regulation of brain-derived neurotrophic factor gene expression. Journal of Pharmacy and Pharmacology. 2014 Jan;66(1):53-61. doi: 10.1111/jphp.12153.
Khundakar, A.A. CV April 2017
deFoubert G, Khundakar AA, Zetterström TS. Effects of repeated 5-HT6 receptor stimulation on BDNF gene expression and cell survival. Neuroscience Letters. 2013, 553C, 211-215.
Gemmell E, Bosomworth H, Khundakar A, Oakley AE, Allan L, Polvikoski TM, Kalaria RN Hippocampal Neuronal Atrophy and Cognitive Function in Delayed Post-Stroke and Ageing-Related Dementias. Stroke. 2012. Mar 43(3) 808-14.
Khundakar AA and Zetterström TSC. Effect of GABA(B) ligands alone, and in combination with paroxetine, on hippocampal BDNF gene expression. The European Journal of Neuropharmacology. 2011. Dec 5;671(1-3):33-8.
Khundakar AA, Morris CM, Oakley AE and Thomas AJ. Cellular pathology within the Anterior Cingulate Cortex of Patients with Late-Life Depression: a Morphometric Study. Psychiatry Research: Neuroimaging. 2011. 194: 184–89.
Khundakar A, Morris C, Oakley A, Thomas AJ. A Morphometric Examination of Neuronal and Glial Cell Pathology in the Orbitofrontal cortex in Late-Life Depression. International Psychogeriatrics. 2011. Feb;23(1):132–40.
Khundakar AA, Morris C, Slade JY and Thomas AJ. An Examination of Glucose Transporter-1, Transforming Growth Factor-β and Neuroglobin Immunoreactivity in the Orbitofrontal Cortex in Late-Life Depression. Psychiatry and Clinical Neurosciences. 2011. Mar;65(2):158–64.
Khundakar AA, Morris CM and Thomas AJ. The Immunhistochemical Examination of GABAergic Interneuron Markers in the Dorsolateral Prefrontal Cortex of Patients with Late-Life Depression. International Psychogeriatrics. 2011. May;23(4):644–53.
Khundakar AA, Morris CM, Oakley AE and Thomas AJ. Morphometric Analysis of Neuronal and Glial Cell Pathology in the Caudate Nucleus. American Journal of Geriatric Psychiatry. 2011. Feb;19(2):132–41.
Khundakar AA, Morris CM, Oakley AE, McMeekin W and Thomas AJ. Morphometric Analysis of Neuronal and Glial Cell Pathology in the Dorsolateral Prefrontal Cortex in Late-life Depression. 2009. British Journal of Psychiatry. 195(2):163–9.
Khundakar AA and Thomas AJ. Morphometric changes in early- and late-life depression: evidence from post-mortem studies. International Psychogeriatrics. 2009. 21(5):844–54.
Banerjee P Aston JC, Khundakar AA and Zetterström TSC. Differential regulation of psychostimulant induced gene expression of brain derived neurotrophic factor and immediate-early gene Arc in the juvenile and adult brain. European Journal of Neuroscience. 2009. 29, 465–476.
Khundakar AA and Zetterström, TSC. Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation. Brain Research. 2006. 1106(1):12–20.
Book Chapters
Khundakar AA, Thomas AJ. The Possible Applications (And Pitfalls!) Of Stereological Analysis In Postmortem Brain Research. In: Mouton, P, ed. Neurostereology: unbiased stereology of neural systems. Hoboken, New Jersey: Wiley-Blackwell. 2014, pp.129-138.
Khundakar AA, Thomas AJ. Neuropathology of Depression in Alzheimer's Disease: Current Knowledge and the Potential for New Treatments. In Journal of Alzheimer's Disease Handbook Volume 4: Depression in Alzheimer’s Disease. 2015. Pages 187 – 201. IOS Press. DOI 10.3233/978-1-61499-542-5-187.

View Ahmad Khundakar's Publications on TeesRep