Research

Current studentships

Exploring novel efflux pumps in environmental acinetobacter spp at the genetic and structural level (BBSRC Yorkshire Bioscience Doctoral Training Partnership)

Deadline: 07/01/2026 5:00PM
Studentship code: PHD
Staff name: Dr Bruno Silvester Lopes
Research centre: National Horizons Centre (Biosciences)
Start date: Successful applicants will be expected to start in October 2026.

Are you passionate about tackling the global challenge of antimicrobial resistance (AMR) understanding the ecological drivers behind what makes a bacterium resistant and how it shapes our world? This PhD project offers you the opportunity to work at the cutting edge of microbiology, genomics, and structural biology to uncover how bacteria evade antibiotics and survive in hostile environments and how they shape our planet's ecosystem.

Acinetobacter spp are among the most problematic causes of hospital-acquired infections worldwide and are listed as a critical priority pathogen by the World Health Organisation. A key factor in their success is efflux pumps proteins that actively pump out antibiotics from the bacterial cell. Our team recently discovered two new environmental Acinetobacter species (Acinetobacter terrae sp. nov. and Acinetobacter Taxon 24C, or SFC and SFB) that carry previously unknown MATE (multidrug and toxin extrusion) efflux pumps. These may represent hidden resistance factors with major implications for both healthcare and environmental survival.

Project Aims
You will adopt an interdisciplinary pipeline, ensuring both feasibility and innovation:
• Use bioinformatics to predict the structure and evolution of novel efflux pumps.
• Apply molecular cloning and expression systems to study their function in laboratory strains.
• Perform antimicrobial susceptibility and efflux assays to link pump activity to resistance and stress adaptation.
• Work with protein purification and cryo-electron microscopy (cryo-EM) to visualise pump structures at near-atomic resolution.

You will be supported by a multidisciplinary supervisory team: Dr Bruno Silvester Lopes (genomics and AMR), Dr Caroline Orr (environmental microbiology, Teesside University), and Professor Jamie Blaza (structural biology, University of York). This means you will receive outstanding training in both experimental and computational methods, gain access to state-of-the-art facilities, and develop highly transferable skills sought after in academia, industry, and public health.
Your research contributes to global AMR strategies, with the potential to identify new drug targets and shape future antimicrobial therapies, and is an exciting opportunity to make a real-world impact.

Funding eligibility

This fully funded PhD Studentship covers tuition fees for the period of a full-time PhD Registration of up to four years and provide an annual tax-free stipend of £21,380 for three years, subject to satisfactory progress.

You must complete your PhD in four years..

Applications are welcome from UK and international students.

Entry requirements

Applicants should hold or expect to obtain a good honours degree (2:1 or above) in a relevant discipline. A masters level qualification in a relevant discipline is desirable, but not essential, as well as a demonstrable understanding of the research area.

Due to the interdisciplinary nature of this programme, we welcome applications if your background is in any biological, chemical or physical science or mathematics and are interested in using your skills in addressing biological questions. International students should check if they meet the entry requirements for the host university.

We aim to support the most outstanding applicants from outside the UK and are able to offer a very limited number of bursaries that will enable full studentships to be awarded to international (EU and non-EU) applicants. These full studentships will only be awarded to exceptional quality candidates, due to the highly competitive nature of this scheme.

International students will be subject to the standard entry criteria relating to English language ability, ATAS clearance and, when relevant, UK visa requirements and procedures.

The YBDTP is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.

Not all projects will be funded; a limited number of candidates will be appointed via a competitive process.

How to apply

To submit your application, complete the Expression of Interest form for any of the projects which interest you. You can apply for up to two YBDTP projects (which can be at different universities).

If you have any questions about the application process, please email ybdtp@leeds.ac.uk

Apply now

Selection process

Shortlisting will take place as soon as possible after the closing date and successful applicants will be notified promptly. If you are shortlisted, you will be invited for an interview on a date to be confirmed in February 2026. You will be notified as soon as possible after the interview dates whether your application has been successful, placed on a reserve list or unsuccessful. If you are successful, you'll be required to confirm your intention to accept the studentship within ten days.

About Teesside

We are committed to providing a safe, welcoming and inclusive campus and to supporting all members of our University community to thrive whatever their age, gender, disability, sexual orientation, gender identity, race, marital status, nationality or any other characteristic.
More about our Inclusive campus

As a Teesside University research student, you will join a growing and dynamic research community, allowing you to share your experiences, insight and inspiration with fellow researchers. You will benefit from our academic expertise and be supported through a strong programme of research training. You will be offered opportunities and support at each stage of your research degree. Our research is designed to have impact, and to influence policy and practice within our region, the UK and beyond. We work with external organisations to anticipate and respond to research needs, and to put our research into practice in sectors as diverse as the arts, engineering, healthcare and computing.

PhD students are encouraged to work with their supervisors to explore the potential impact of their work.

The successful candidate will be expected to participate fully in research group and centre activities, including training sessions and workshops, and will become a member of the University's wider postgraduate research community. Mentoring and support will be provided for the development of a strong academic and professional CV during the PhD.

The YBDTP brings together world-class bioscience research and innovation, as well as excellence in doctoral supervision, across the Yorkshire and Teesside region. The YBDTP will fund postgraduate researchers at the Universities of Leeds, Sheffield, York, Bradford, Huddersfield, Hull, Leeds Beckett, Sheffield Hallam and Teesside forming a strong regional training partnership. In YBDTP you'll benefit from a regional doctoral training programme that has interdisciplinary collaboration at its core. The aim is to enable you to develop a range of research skills in biological, biotechnology and biochemical areas as well as equip you with core data analysis and professional skills that are necessary for bioscience research and related non-academic careers. Yorkshire Bioscience Doctoral Training Partnership

Academic enquiries

For academic enquiries, please contact b.lopes@tees.ac.uk.

Key dates

Deadline: 07/01/2026 5:00PM
Interview date: We envisage that interviews will take place in February 2026.
Start date: Successful applicants will be expected to start in October 2026.